Click Here to return To Results

 

Prevent of a 1st Stroke by Transfusions in Children/Sickle Cell Anemia & Abnorm Results on Transcr Doppler Ultrasonog NEJM 339:5-11, Adams,R.J.,et al, 1998 See this aricle in Pubmed Article Abstract A total of 130 children were enrolled,63 were randomly assigned to receive transfusions and 67 to receive standard care.At baseline,the transfusion group had a slightly lower mean hemoglobin concentration and hematocrit. Ten patients dropped out of the transfusion group,and two patients crossed over from the standard-care group to the transfusion group.There were 10 cerebral infarctions and 1 intracerebral hematoma in the standard-care group to the transfusion group,as compared with 1 infarction in the transfusion group-a 92%difference in the risk of stroke.This result led to the early termination of the trial.Transfusion greatly reduces the risk of a first stroke in children with sickle cell anemia who have abnormal results in transcranial Doppler ultrasonography.

Related Tags

(click to filter results - removes previous filter) blood transfusion carotid artery disease,noninvasive evaluation of carotid artery stenosis carotid artery stenosis,intracranial cerebral infarction cerebrovascular accident cerebrovascular accident,infancy and childhood cerebrovascular accident,prevention of children doppler doppler,transcranial prevention of neurologic disorders prognosis risk factors sickle cell disease

Click Here to return To Results